logo

Governance & Mission

Together to accelerate innovation

Carnot CALYM Institute promotes innovation in lymphoma research and accelerates its transfer to the clinic and the healthcare industry through public/private partnerships.

CALYM’s R&D offering is positioned in a fast-growing global pharmaceuticals and biotechnology market, which for several years has been undergoing a strategic shift involving a strong need for biological, clinical and technological expertise from the academic sector. To meet these market demands, CALYM is uniquely positioned across the entire R&D value chain, from the identification of new cellular targets to international Phase III clinical trials and beyond.

The Steering Committee of the CALYM Carnot Institute is made up of the statutory representatives of the member entities. It is currently chaired by Prof. Guillaume Cartron.

 

Membres Organisation
Guillaume Carton Responsable du pôle Cancérologie Médecin et Immunologie, Responsable du service Hématologie clinique CHU Montpellier / Président du COPIL
Bertrand Nadel Centre D’immunologie De Marseille-Luminy / Directeur De l’Institut Carnot Calym
Pascale Augé Présidente du Directoire, Inserm Transfert / Représentante Inserm Transfert
Catherine Chassagne Chargée de mission Innovation et partenariats industriels INSB / Représentante INSB
Bruno Danic Directeur Etablissement Français Du Sang Bretagne / Représentant EFS
Yvan De Launoit Directeur adjoint scientifique  « Physiologie, Vieillissement, Tumorigenèse » Insb / Représentant Cnrs
Alain Eychene Directeur de l’institut thématique Cancer, Directeur de l’ITMO cancer d’AVIESAN, Directeur du pôle recherche et innovation de l’institut national du cancer / Représentant ITMO
Michel Cogné Centre De Biologie Et Recherche En Sante, Faculte De Medecine De Limoges / Représentant Des Equipes Calym, membre invité
Célia Loukili Directrice générale et financière Association Calym, membre invité
Loïc Ysebaert Oncopole Toulouse / Représentant Des Equipes Calym, membre invité
Together to accelerate innovation
2

Network

of the Carnot Calym Institute

To meet market demand, CALYM is uniquely positioned across the entire R&D value chain, from excellent fundamental research to clinical trials for drug registration.

The multi-disciplinary expertise required is ensured by the combination of 19 entities: a network of 17 public laboratories conducting excellent research in the field of lymphoma, and 2 private non-profit organisations, international leaders in clinical and translational lymphoma research. Together, they form a coherent structure, coordinated by a professional operational team.

The complementary expertise of CALYM’s 19 member entities covers all lymphoma subtypes and the related cutting-edge fields of fundamental, translational and clinical research (fundamental biological discoveries and new therapeutic targets, predictive/diagnostic/theranostic biomarkers, manipulation of the tumour microenvironment, oncoimmunology, cell therapy, -omics, signaling, etc.).

Calym offers integrated expertise enabling :

  • scientific and clinical evaluation of the biological rationale for candidate therapeutic mechanisms or molecules
  • relevant market positioning
  • the biotechnology expertise required to build ambitious research programmes in industrial partnership
  • the institutional infrastructure
  • the staff needed to carry out these programmes
  • the interface between academic and industrial know-how, practices and standards

carte de france

Tous les experts

0
Public Labs
0
Non-profit private organisations
0
Operational team
3

Carnot Label

The number one player in partnership research

The Carnot network is the leading player in partnership-based research in France, with 11,000 industrial R&D contracts and more than 100 high-tech start-ups launched every year. The Carnot network brings together 35,000 professionals in 39 institutes approved by the French Ministry of Research, with a key mission: to build the economic and industrial future by supporting companies in their strategies to differentiate through innovation.

CALYM is one of the Carnot Institutes with the highest volume of partnered research, the majority of which is international. A noteworthy achievement.

Calym’s initiative to create an academic investment centre, with the mission of developing partnership research in the field of oncology-haematology, has just been awarded the « Innovation Team Best Practices » trophy.

This award is conferred each year by the Club de Paris des Directeurs de l’Innovation to the teams that best embody innovation in all sectors and all organisations: further proof of its excellence and dynamism.

0
Industrial R&D contracts
0
Start-ups per year
0
Professionals
0
Certified institutes
Top 10
[Update on marginal zone lymphoma classification, diagnosis and treatment in 2024].

Lucie Oberic, Krimo Bouabdallah, Sylvain Carras, Catherine Thieblemont
Bull Cancer.2025 03
DOI: 10.1016/j.bulcan.2025.01.013
Publication
Top 10
Metabolic Heterogeneity in Diffuse Large B-Cell Lymphoma Cells Reveals an Innovative Antimetabolic Combination Strategy.

Leonardo Lordello, Stéphanie Nuan-Aliman, Karoline Kielbassa-Elkadi, Aurélie Montagne, Konstantina Kotta, Isabelle Martins, Eva Pinto Jurado, Cédric Caradeuc, Jacqueline Lehmann-Che, José Ángel Martínez-Climent, Véronique Meignin, Nicolas Giraud, Guido Kroemer, Gildas Bertho, Catherine Thieblemont, Véronique Baud
Cancers (Basel).2025 01
DOI: 10.3390/cancers17030394
Publication
Top 10
A low lymphocyte-to-monocyte ratio is independently associated with early relapse (POD24) in high tumour burden follicular lymphoma: A RELEVANCE subanalysis.

Pablo Mozas, Romain Ould Ammar, Loïc Chartier, Loretta Nastoupil, Emmanuel Bachy, Silvia Maria Bezsera, Jeffrey Barnes, Fontanet Bijou, André Goy, Hacène Zerazhi, Guillaume Cartron, Mario Ojeda-Uribe, Sylvain Choquet, Bertrand Joly, Morgane Cheminant, Alejandro Martín García-Sancho, Herbert Eradat, Rémy Gressin, Pau Abrisqueta, Anne Parcelier, María José Rodríguez Salazar, Christophe Bonnet, Nathalie A Johnson, Armando López-Guillermo, Franck Morschhauser
Br J Haematol.2025 03
DOI: 10.1111/bjh.20038
Publication
Top 10
Efficacy of tazemetostat in combination with R-CHOP in elderly patients newly diagnosed with diffuse large B cell lymphoma: results of the EpiRCHOP phase II study of the LYSA.

Clémentine Sarkozy, Thierry Jo Molina, Sydney Dubois, Cédric Portugues, Elodie Bohers, Loic Ysebaert, Roch Houot, Gian Matteo Pica, Philippe Ruminy, Charles Herbaux, Thomas Gastinne, Catherine Thieblemont, Corinne Haioun, Stéphanie Guidez, Christophe Bonnet, Gilles Crochet, Liana Veresezan, Sylvain Choquet, Emmanuel Bachy, Fabrice Jardin, Franck Morschhauser, Vincent Ribrag
EClinicalMedicine.2025 03
DOI: 10.1016/j.eclinm.2025.103157
Publication
Top 10
Mosunetuzumab plus Pola-CHP compared with Pola-R-CHP in previously untreated DLBCL: final results from a Phase II study.

Jason R Westin, Tycel J Phillips, Amitkumar Mehta, Marc S Hoffmann, Eva Gonzalez-Barca, Catherine Thieblemont, Mariana Bastos-Oreiro, Richard Greil, Sebastian Giebel, Michael C Wei, Jue Wang, Reinhard Bucher, Jason Sit, Elicia Penuel, Enkhtsetseg Purev, Donald L Yee, Juan Miguel Bergua Burgues
Blood Adv.2025 02
DOI: 10.1182/bloodadvances.2024014907
Publication
Top 10
Outcomes of patients with relapsed or refractory primary mediastinal B-cell lymphoma treated with anti-CD19 CAR-T cells: CARTHYM, a study from the French national DESCAR-T registry.

Jean Galtier, Charles Mesguich, Pierre Sesques, Vivien Dupont, Emmanuel Bachy, Roberta Di Blasi, Catherine Thieblemont, Thomas Gastinne, Guillaume Cartron, Gabriel Brisou, François-Xavier Gros, Justine Decroocq, Franck Morschhauser, Marie-Thérèse Rubio, Laurianne Drieu La Rochelle, Fabien Le Bras, Sylvain Carras, Adrien Chauchet, Jacques-Olivier Bay, Magalie Joris, Mickael Loschi, Aline Tanguy-Schmidt, Alexandra Marquet, Vincent Camus, Steven Le Gouill, Roch Houot, Krimo Bouabdallah
Hemasphere.2025 02
DOI: 10.1002/hem3.70091
Publication
Top 10
to: Bendamustine and rituximab as first-line treatment for symptomatic splenic marginal zone lymphoma: long-term outcome and impact of early unmeasurable minimal residual disease attainment from the BRISMA/IELSG36 phase II study.

Emilio Iannitto, Simone Ferrero, Côme Bommier, Daniela Drandi, Martina Ferrante, Krimo Bouabdallah, Sylvain Carras, Guido Gini, Vincent Camus, Salvatrice Mancuso, Luigi Marcheselli, Angela Ferrari, Michele Merli, Benoit Tessoulin, Caterina Stelitano, Kheira Beldjord, Giovanni Roti, Fabrice Jardin, Barbara Castagnari, Francesca Palombi, Lucile Baseggio, Alexandra Traverse-Glehen, Claudio Tripodo, Anna Marina Liberati, Margherita Parolini, Sara Usai, Caterina Patti, Massimo Federico, Maurizio Musso, Marco Ladetto, Emanuele Zucca, Catherine Thieblemont
Haematologica.2025 04
DOI: 10.3324/haematol.2024.287031
Publication
Top 10
Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines.

Loïc Renaud, Marie Donzel, Justine Decroocq, Pierre Decazes, Jean Galtier, Barbara Burroni, Elena-Liana Veresezan, Côme Sesboüé, Peggy Dartigues, Catherine Chassagne-Clément, Laurent Martin, Claire Mauduit, Sophie Kaltenbach, Dominique Penther, Pascaline Etancelin, David Sibon, Sarah Bailly, Valentine Martin, Eric Durot, Youlia Kirova, Adrien Grenier, Marie Maerevoet, Wivine Bernard, Louise Naveau, Aurélie Cabannes-Hamy, Anne-Ségolène Cottereau, Nicolas Jacquet-Francillon, Robin Noel, Thibaut Reichert, Clémentine Sarkozy, Lucile Bussot, Sébastien Bailly, Sandy Amorim, Daphné Krzisch, Jérôme Cornillon, Hugo Legendre, Florian Chevillon, Doriane Cavalieri, Pierre Sesques, Véronique Minard-Colin, Corinne Haioun, Franck Morschhauser, Roch Houot, Fabrice Jardin, Hervé Tilly, Alexandra Traverse-Glehen, Vincent Camus
Eur J Cancer.2025 03
DOI: 10.1016/j.ejca.2025.115369
Publication
Top 10
Prognostic impact of metabolic tumor volume using the SUV4.0 segmentation threshold in 1,960 lymphoma patients from prospective LYSA trials.

Solène Malmon, Mad-Helenie Elsensohn, Catherine Thieblemont, Franck Morschhauser, Olivier Casasnovas, Marc André, Steven Le Gouill, Yassine Al Tabaa, Paul Bland Durand, Clement Bailly, Veronique Edeline, Lavinia Vija, Laetitia Vercellino, Romain Ricci, Salim Kanoun, Anne-Ségolène Cottereau
Eur J Nucl Med Mol Imaging.2025 03
DOI: 10.1007/s00259-025-07176-4
Publication
Top 10
Interim PET after 4 Cycles Predicts Outcome in Histomolecularly Confirmed Primary Mediastinal B-Cell Lymphoma.

Vincent Camus, Thierry Jo Molina, Fabienne Desmots, Paul Blanc-Durand, Salim Kanoun, Amine Moslemi, Philippe Ruminy, Steven Le Gouill, Herve Ghesquieres, Lucie Obéric, Franck Morschhauser, Hervé Tilly, Vincent Ribrag, Roch Houot, Catherine Thieblemont, Herve Gerard Maisonneuve, Fabien Claves, Krimo Bouabdallah, Corinne Haioun, Gandhi Damaj, Luc-Mathieu Fornecker, Robin Noel, Pierre Feugier, David Sibon, Guillaume Cartron, Christophe Bonnet, Wivine Bernard, Françoise Kraeber-Bodere, Caroline Bodet-Milin, Jean-Philippe Jais, Josette Briere, Cédric Rossi, Mad-Hélénie Elsensohn, Loïc Chartier, Emmanuel Itti, Fabrice Jardin, Thierry Fest
Blood Adv.2025 03
DOI: 10.1182/bloodadvances.2024015577
Publication
Top 10
Validation of POD24 as a robust early clinical indicator of poor survival in mantle cell lymphoma from 1280 patients on clinical trials, a LYSA study.

Clémentine Sarkozy, Loïc Chartier, Vincent Ribrag, Remy Gressin, Christian H Geisler, Hanneke C Kluin-Nelemans, Catherine Thieblemont, Franck Morschhauser, François Lemonnier, Violaine Safar, Benoît Tessoulin, Lucie Oberic, Ghandi Damaj, Hervé Ghesquières, Krimo Bouabdallah, René Olivier Casasnovas, Roch Houot, Wolfram Klapper, Barbara Burroni, Christiane Pott, Marie-Hélène Delfau-Larue, Elizabeth Macintyre, Mary Callanan, Mats Jerkeman, Michael Unterhalt, Eva Hoster, Martin Dreyling, Steven Le Gouill, Olivier Hermine, Morgane Cheminant
Blood Cancer J.2025 04
DOI: 10.1038/s41408-025-01241-9
Publication
Top 10
TP53 Mutations Detected by NGS Are a Major Clinical Risk Factor for Stratifying Mantle Cell Lymphoma.

Grégory Lazarian, Lotfi Chemali, Merieme Bensalah, Carla Zindel, Valérie Lefebvre, Catherine Thieblemont, Antoine Martin, Giulia Tueur, Rémi Letestu, Carole Fleury, Vincent Leymarie, Valérie Vidal, Audrey Bidet, Elsa Maitre, Florence Cymbalista, Vincent Levy, Thierry Soussi, Fanny Baran-Marszak
Am J Hematol.2025 03
DOI: 10.1002/ajh.27650
Publication
Top 10
Myeloid neoplasms after CD19-directed CAR T cells therapy in long-term B-cell lymphoma responders, a rising risk over time?

Nicolas Gazeau, David Beauvais, Rémi Tilmont, Micha Srour, Emmanuelle Ferrant, Violaine Safar, Ludovic Fouillet, Pascale Flandrin-Gresta, Nicolas Gower, Paul Chauvet, Nicolas Duployez, Benjamin Podvin, Julie Demaret, Sarah Huet, Pierre Sujobert, Hervé Ghesquières, Gandhi Damaj, Emmanuel Bachy, Franck Morschhauser, Ibrahim Yakoub-Agha, Maël Heiblig, Pierre Sesques
Leukemia.2025 04
DOI: 10.1038/s41375-025-02605-7
Publication
Top 10
Author Correction: Odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma: primary efficacy and safety analysis in phase 2 ELM-2 trial.

Won Seog Kim, Tae Min Kim, Seok-Goo Cho, Isidro Jarque, Elżbieta Iskierka-Jażdżewska, Li Mei Poon, H Miles Prince, Huilai Zhang, Junning Cao, Mingzhi Zhang, Benoît Tessoulin, Sung Yong Oh, Francesca Lim, Cecilia Carpio, Tran-Der Tan, Sabarish Ayyappan, Antonio Gutierrez, Jingxian Cai, Melanie Ufkin, Saleem Shariff, Jurriaan Brouwer-Visser, Aafia Chaudhry, Hesham Mohamed, Srikanth Ambati, Jan Walewski
Nat Cancer.2025 04
DOI: 10.1038/s43018-025-00967-6
Publication
Top 10
Glofitamab in refractory or relapsed diffuse large B cell lymphoma after failing CAR-T cell therapy: a phase 2 LYSA study.

Guillaume Cartron, Roch Houot, Yassine Al Tabaa, Fabien Le Bras, Loïc Ysebaert, Sylvain Choquet, Fabrice Jardin, Jacques-Olivier Bay, François-Xavier Gros, Franck Morschhauser, Olivier Casasnovas, Thomas Gastinne, Catherine Thieblemont, Magalie Joris, Laure Ricard, Caroline Regny, Laurianne Drieu La Rochelle, Pierre Feugier, Ambroise Marcais, Samuel Griolet, Karin Tarte, Camille Laurent, Pierre Sesques
Nat Cancer.2025 04
DOI: 10.1038/s43018-025-00941-2
Publication
Top 10
Odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma: primary efficacy and safety analysis in phase 2 ELM-2 trial.

Won Seog Kim, Tae Min Kim, Seok-Goo Cho, Isidro Jarque, Elżbieta Iskierka-Jażdżewska, Li Mei Poon, H Miles Prince, Huilai Zhang, Junning Cao, Mingzhi Zhang, Benoît Tessoulin, Sung Yong Oh, Francesca Lim, Cecilia Carpio, Tran-Der Tan, Sabarish Ayyappan, Antonio Gutierrez, Jingxian Cai, Melanie Ufkin, Saleem Shariff, Jurriaan Brouwer-Visser, Aafia Chaudhry, Hesham Mohamed, Srikanth Ambati, Jan Walewski
Nat Cancer.2025 03
DOI: 10.1038/s43018-025-00921-6
Publication
Top 10
Three-year follow-up analysis of first-line axicabtagene ciloleucel in high-risk large B-cell lymphoma (ZUMA-12).

Julio C Chavez, Michael Dickinson, Javier Munoz, Matthew L Ulrickson, Catherine Thieblemont, Olalekan O Oluwole, Alex F Herrera, Chaitra Ujjani, Yi Lin, Peter A Riedell, Natasha Kekre, Sven de Vos, Jacob Wullf, Chad M Williams, Joshua Winters, Ioana Magdalena Kloos, Hairong Xu, Sattva S Neelapu
Blood.2025 02
DOI: 10.1182/blood.2024027347
Publication
Top 10
Ibrutinib plus venetoclax in relapsed or refractory mantle cell lymphoma (SYMPATICO): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study.

Michael Wang, Wojciech Jurczak, Marek Trneny, David Belada, Tomasz Wrobel, Nilanjan Ghosh, Mary-Margaret Keating, Tom van Meerten, Ruben Fernandez Alvarez, Gottfried von Keudell, Catherine Thieblemont, Frederic Peyrade, Marc Andre, Marc Hoffmann, Edith Szafer-Glusman, Jennifer Lin, James P Dean, Jutta K Neuenburg, Constantine S Tam
Lancet Oncol.2025 02
DOI: 10.1016/S1470-2045(24)00682-X
Publication