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Early Steps of Haematopoietic Transformation

Leader: Olivier Bernard

VillejuifUMR 1170 -
Institut Gustave Roussy

Research Areas & Objectives

Research areas

TET2 and normal and pathological haematopoiesis

Objectives

The overall aim of the group is to identify the acquired mutations in the early step of haematopoietic transformation, understand the network of cooperating events underlying transformation and develop experimental models to allow functional investigations and serve as preclinical models.

In particular, the team is investigating the role of TET2/3 and of 5mC/5hmC epigenetic marks in normal and malignant of both T-lymphoid and myeloid differentiation and is studying the cooperation between TET2 and DNMT3A mutations in transformation.

Lymphoma Sub-types

Mantle-cell lymphoma

Expertise

Biological targets and in vitro/in vivo/ex vivo models

Targets
- TET2
- TET3
- DNMT3A

Models
Mantle-cell lymphoma cell lines and mouse models

Innovative Technologies

NS, whole exome

Platforms & Technical Resources

The laboratory has access to the different platforms Gustave Roussy Institute:
- Department of Integrated Biology (PBI) (NGS and Genomics, Proteomics, Metabolomics)
- Translational Research Laboratory (LRT)
- Biological Resources Centre (CRB)
- Imaging Flow Cytometry Platform
- Bioinformatics Platforms
- Immunomonitoring in Oncology Laboratory (LIO)
- Pre-clinical Evaluation Unit (PFEP)

R&D Offer

- Preclinical evaluation of molecules (efficacy / toxicity, in combination and/ or in monotherapy) on in vivo and in vitro mantle cell lymphoma models
- Biomarker assays development in phase I trials
- Molecular screening in phase I trials

Keywords

TET2, TET3, Hematopoiesis, Epigenetics, Differentiation

 

Please, download our presentation poster (.pdf)