Immunity and Cancer

Daniel Olive

Marseille1068 INSERM UMR
Cancer Research Center of Toulouse (CRCT)

Research Areas & Objectives

- Alterations of innate immunity associated to cancers
- Molecules of immune co-signaling and co-stimulation
- Role of the immune system in the microenvironment of lymphoproliferations
- Acquired immunodeficiencies related to cancer
- PI-3K signaling pathway
- Immunomonitoring of biotherapies in cancerology

Lymphoma Sub-types

- T-cell lymphomas
- Follicular lymphoma
- Hodgkin lymphoma
- Diffuse large B cell lymphoma

Expertise

Biological targets and in vitro/in vivo/ex vivo models

Targets:
- Co-signaling molecules and innate immunity in cancer
- CD28/B7 molecule family (CD28, CTLA-4, PD-1, ICOS, BTLA) and their ligands (CD80, CD86, PD-L1, PD-L2, ICOSL, BTN3A) and TNF/TNR family (HVEM/TNFRSF14, LIGHT/TNFSF14)

Models:
- Ex-vivo cultures
- Immunodéficient mice
- KO and KI models

Blood and tissue biomarkers

Co-signaling molecules and lymphomas

Early pharmacodynamic signs of activity

Co-stimulation of T-cells and phosphatidyl-inositol 3’-kinase (PI-3K) signaling pathway

Tools, processes and platforms in connection with clinical research

- Immunohistochemistry
- Generation of monoclonal antibodies
- IBiSA platform of cancers immunomonitoring (K-Cytof)
- Advanced Flow cytometry
- Regional platform of somatic molecular oncogenetics

Innovative Technologies

- Monoclonal antibody generation
- ADCC NK assay in cellular in vitro models of lymphoma patients
- K-Cytof (Helios)
- Serum biomarkers developement
- RNAseq
- Polychromatic flow cytometry

Platforms & Technical Resources

- Cancer immunomonitoring: Phase 1 studies
- Preclinical models
- Works on patients samples
- Polychromatic flow cytometry
- IHC

R&D Offer

- Collaborative projects
- Expertise in immunology related to cancer
- Setup of immunomonitoring projects
- Training for master and PhD including “Master Pro” of flow cytometry
- Access to immunological databases from lymphoma patients
- ADCC NK assay in in vitro cell models of lymphoma patients
- Immunomonitoring
- Immune biomarkers analysis (flow cytometry)

Keywords

Co-signaling molecules, Microenvironment, Innate immunity, Immunodeficiency related to cancer

Please, download our presentation poster (.pdf)

Research projects